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<p>ATS are a heterogenous group of natural and synthetic compounds related to AMPH. The chemist Lazăr Edeleanu was the first to synthesize AMPH in the 1880s but did not perform a pharmacological characterization (Fig. 1). Later, Nagai Nagayoshi isolated ephedrine from the Chinese herbal medicine Ephedra spp. and synthesized METH in 1893. Due to its bronchodilator and adrenaline-like actions, ephedrine was successfully introduced into the United States (U.S.) and Europe in the 1920s as a decongestant and asthma-relieving drug. In 1927, while searching for a substitute for ephedrine, Gordon Alles synthesized racemic AMPH and studied its effects in animals and humans, finding that it increased arousal and produced insomnia. Its clinical use began when Smith, Kline, and French Co. introduced AMPH into the market in 1935 under the name of Benzedrine® to treat narcolepsy, post-encephalitic parkinsonism, and depression. A few years later, the same pharmaceutical company introduced the more potent isomer dextro-AMPH (d-AMPH) marketed as Dexedrine®2. Benzedrine was freely available as a decongestant inhaler containing a cotton strip soaked in volatile AMPH oil. People soon realized that they could inhale AMPH to experience psychostimulant effects and it became extremely popular. Only in 1939 was a prescription required to buy Benzedrine and Dexedrine. At approximately the same time, Charles Bradley, an American psychiatrist, administered Benzedrine to 30 children with behavioral disorders and found a significant improvement in their school and social performance. Bradley published his findings in 1937, but this contribution remained unnoticed by the medical community for a couple of decades. However, his study became the basis for using stimulants for ADHD treatment. Buy Amphetamine powder online.
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<p>ATS are sympathomimetic substances with effects and chemical structures similar to the monoamine neurotransmitters dopamine, noradrenaline, and serotonin. From the chemical point of view, ATS are phenethylamine derivatives with (a) an unsubstituted phenyl ring, (b) a two-carbon chain between the phenyl ring and the nitrogen atom, (c) an α-methyl group, and (d) the primary amino group. MDMA and its analogs contain the phenethylamine and a methylenedioxy ring, making them similar also to serotonin. On the other hand, cathinones differ from AMPHs in the presence of a ketone group (-C=O) bound to the β-carbon in the phenylethylamine (Fig. 2).</p>
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<p>The behavioral and cognitive effects of ATS are related to indirect monoamine release. AMPH and METH mainly release catecholamines. MDMA and its derivatives release catecholamines and serotonin; and cathinones have a mixed mechanism of action (see below). Acute ATS administration generally increases arousal, blood pressure, and heart rate. They produce mydriasis, euphoria, and talkativeness, enhances motivation, reduces appetite, and causes insomnia (Fig. 3). High doses or chronic use of ATS cause anxiety, paranoia, cognitive deficits, and psychosis. Hyperthermia and serotonin syndrome can occur with high doses of several ATS. As with other misused substances, psychostimulant repeated use can produce addiction.</p>
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Nausea, stomach upset, diarrhea, dry mouth, headache, nervousness, dizziness, trouble sleeping, loss of appetite, weight loss, irritability, or restlessness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Buy Amphetamine powder online
This medication may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high.
Tell your doctor right away if you have any serious side effects, including: signs of blood flow problems in the fingers or toes (such as coldness, numbness, pain, or skin color changes), unusual wounds on the fingers or toes, mental/mood/behavior changes (such as agitation, aggression, mood swings, depression, thoughts of suicide, hallucinations, abnormal thoughts/behavior), uncontrolled muscle movements (such as twitching, shaking), outbursts of words/sounds, swelling ankles/feet, extreme tiredness, change in sexual ability/interest, frequent/prolonged erections (in males), vision changes (such as blurred vision).
Get medical help right away if you have any very serious side effects, including: fainting, severe headache, fast/pounding/irregular heartbeat, seizures, symptoms of a heart attack (such as chest/jaw/left arm pain, shortness of breath, unusual sweating), symptoms of a stroke (such as weakness on one side of the body, trouble speaking, sudden vision changes, confusion).
This medication may increase serotonin and rarely cause a very serious condition called serotonin syndrome/toxicity. The risk increases if you are also taking other drugs that increase serotonin, so tell your doctor or pharmacist of all the drugs you take (see Drug Interactions section). Get medical help right away if you develop some of the following symptoms: fast heartbeat, hallucinations, loss of coordination, severe dizziness, severe nausea/vomiting/diarrhea, twitching muscles, unexplained fever, unusual agitation/restlessness.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
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Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.
Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Avoid taking MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication. Ask your doctor when to start or stop taking this medication.
Some products have ingredients that could raise your heart rate or blood pressure. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen).
The risk of serotonin syndrome/toxicity increases if you are also taking other drugs that increase serotonin. Examples include street drugs such as MDMA/ “ecstasy,” St. John’s wort, certain antidepressants (including SSRIs such as fluoxetine/paroxetine, SNRIs such as duloxetine/venlafaxine), among others. The risk of serotonin syndrome/toxicity may be more likely when you start or increase the dose of these drugs.
Amphetamine is very similar to dextroamphetamine or lisdexamfetamine. Do not use medications containing dextroamphetamine or lisdexamfetamine while using amphetamine. Buy Amphetamine powder online.
This medication may interfere with certain medical/laboratory tests (including blood and urine steroid levels, brain scan for Parkinson’s disease), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.
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